Salmonella, a genus of rod-shaped, Gram-negative bacteria, comprises two species, Salmonella enterica (S. enterica) and Salmonella bongori (S. bongori). S. enterica is subdivided into more than 2,000 serovars, of which Salmonella Typhi (S. Typhi) infects only humans and is a leading agent for typhoid fever, also known as enteric fever, a potentially fatal disease that causes multi-systemic illness1. In total, approximately 21 million new cases of typhoid fever and over 200,000 deaths annually occur worldwide. Even in a developed country, such as the USA, approximately 6,000 new cases of typhoid fever occur each year. Currently, the principal method to diagnose typhoid fever is TYPHIDOT, a rapid immunoassay test to detect IgM and IgG antibodies against the outer-membrane protein ST50 of S. Typhi. ST50, an outer-membrane protein with the molecular mass of approximately 50 kDa, is expected to be a tripartite member of the resistance-nodulation-cell division (RND) efflux system because of its high sequence identity with TolC (89%), one component of the drug efflux system AcrA-AcrB-TolC in E. coli. Here you can see the crystal structure of an antigenic outer membrane protein ST50 from Salmonella Typhi (PDB code: 5BUN)

#molecularart #salmonella #outer #membrane #st50 #antigenic #xray

Structure rendered with @proteinimaging, post-processed with @stylar.ai_official and depicted with @corelphotopaint